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Cancers Webinar | Epigenetic and Metabolic Alterations in the Tumor Microenvironment II

16 Dec 2020, 00:00

Tumor Microenvironment, Hypoxia, Inflammation, Cytokines, Epigenetics, Metabolic Crosstalk
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Cancers Webinar

Epigenetic and Metabolic Alterations in the Tumor Microenvironment

The present webinars are linked to the Cancers Special Issue on “Epigenetic and Metabolic Alterations in the Tumor Microenvironment”.

The intercellular communications between the malignant cancer cells and the cancer-associated fibroblasts and immune cells present in the stroma leads to the continuous remodeling of the tumor microenvironment, which then impinges on the progression of cancer. In this scenario, epigenetic changes caused by microenvironmental factors play a major role in metabolic reprogramming and consequently in the behavior of cancer cells.

There are two webinar sessions on 15 December 2020 and 16 December 2020.

In these webinars, the invited speakers will present the state-of-art of the current researches on the epigenetic and metabolic alterations occurring in the tumor environment that influence cancer progression through impacting the proliferation

Date: 16 December 2020

Time: 3:00 p.m. (CEST) | 9:00 a.m. (EDT) | 9:00 p.m. (CST Asia)

Chair: Prof. Dr. Danny Dhanasekaran

Prof. Dr. Danny N. Dhanasekaran

Dr. Danny Dhanasekaran received his Ph.D. in Biochemistry from the Indian Institute of Science, India and postdoctoral training at the University of Wisconsin-Madison, Wisconsin and National Jewish Center for Cancer Research and Respiratory Medicine at Denver, Colorado. After rising to the rank of Professor of Biochemistry at Temple University School of Medicine, Philadelphia, he joined the University of Oklahoma Health Science Center as the Professor of Cell Biology, Samuel Noble Foundation Endowed Chair in Cancer Research, and Deputy Director for Basic Research of the Stephenson Cancer Center. His academic honors include WCU Professorship at the Seoul National University, Seoul, S. Korea, Visiting Professor of Tokyo Medical and Dental University, Tokyo, Japan, and Visiting Professorship in Università del Piemonte Orientale, Novara, Italy. He has published more than 100 peer-reviewed publications. His current research is focused on defining the role of coding and non-coding RNAs in tumor microenvironment and tumor progression along with a focus on developing novel cancer therapeutics.

The following experts will present:

Prof. Dr. Ciro Isidoro

Dr Ciro Isidoro is Full Professor of General Pathology and Clinical Pathology at the Department of Health Sciences, Università del Piemonte Orientale (Novara, Italy). His laboratory has a consolidated experience in the biogenesis and function of lysosomal proteases, and in alterations of the autophagy-lysosomal proteolysis in cancer. Emphasis is given to the study of protein–protein interactions and to the subcellular localization of the protein of interest in order to understand its altered function. Researches focus on the mechanism of action of nutraceuticals and probiotics in the epigenetic regulation of autophagy and of cell death in 3D heterotypic organoid cancer models.

Dr Eric Hervouet

Dr Eric Hervouet’s researches focus on Epigenetics and Cancer. Several different axes are studied in the lab: i) they try to better characterize the Epigenetic regulation and the role of epigenetic writers involved in epithelial mesenchymal transition (EMT) in cancer, a phenomenon thinly related to metastasis; ii) they also investigate how autophagy is epigenetically regulated in breast cancer models and whether epidrugs could be used to modulate autophagy and cancer-related phenotypes; iii) they aim at characterizing and modulating the epigenetic plasticity of T-cell infiltrating Tumors towards an immune profile of better prognosis.

Dr. Umber Cheema

Professor Cheema has been instrumental in the development of 3D tumouroids, which are in vitro models of solid tumour growth. Here the spatial micro-architecture of a tumour and its surrounding stroma has been reproduced in vitro, with evidence of tumour invasion into surrounding 'normal' tissue and interaction of the cancer with engineered vascular networks. The development of humanised in vitro models is a key aspect of her research as well as incorporation of patient derived cells. Professor Cheema was part of the team to develop a novel plastic compression technique for collagen I hydrogels, which is now patent protected. Her research also focuses on controlling elements of collagen architecture to engineer biomimetic tissues in vitro for the musculoskeletal system.

Dr. Rainer Glauben

Rainer Glauben works as PI in the lab of Prof. Britta Siegmund at the Charité - Universitätsmedizin Berlin in the Department of Gastroenterology, Infectiology and Rheumatology. The main subjects of his work are the mechanisms of intestinal inflammation with special emphasis on myeloid cells but also the epithelial barrier. Additionally, he is interested in the immune evasion of tumors regarding the regulatory function of myeloid cells as well as CD8+ T cell activation. Both subjects are investigated regarding the metabolic changes in the local microenvironment and epigenetic regulation of the respective cells via histone deacetylases.

Program

Speakers/Presentation Time CET

Time EDT

Time CST Asia

Prof. Dr. Ciro Isidoro

"How soluble factors in the tumor microenvironment affect cancer cell metabolism and cancer progresion: focus on autophagy"

3:00pm

Q&A (10 min)

9:00am

9:00pm

Dr Eric Hervouet

"EZH2 and KDM6B are associated with specific epigenetic signatures during EMT in Non Small Cell Lung Carcinomas "

3.35pm

Q&A (10 min)

9.35am 9.35pm

Dr. Umber Cheema

"Bioengineering 3D tumouroids to interrogate the tumour-stroma boundary"

4.10pm

Q&A (10 min)

10.10am 10.10pm

Dr. Rainer Glauben

"Lipid droplet dependent fatty acid metabolism modulates the polarization of tumor associated macrophages"

4.45pm

Q&A (10 min)

10.45am 10.45pm

Webinar Content

The Cancers Webinar - Epigenetic and Metabolic Alterations in the Tumor Microenvironment II, held on December 16, 2020 and chaired by Prof. Dr. Ciro Isidoro and Prof. Dr. Danny N. Dhanasekaran was a success. With over 100 enrolled from all over the world, the chairs and four presenters continued the serie of talks and discussions that were started on the first webinar of the topic: how epigenetic and metabolic alterations occurring in the tumor environment could influence cancer progression.

Prof. Dr. Danny N. Dhanasekaran and Prof. Dr. Ciro Isidoro introduced the topic and presented the speakers. Prof. Dhanasekaran himself, started the session with a presentation on "LncRNAs and Cancer Epigenome". Dr Eric Hervouet followed him presenting his research on EZH2 and KDM6B are associated with specific epigenetic signatures during EMT in Non Small Cell Lung Carcinomas. Dr. Umber Cheema continued with her presentation on "Bioengineering 3D tumouroids to interrogate the tumour-stroma boundary". Dr. Rainer Glauben contributed to the topic presenting his talk in "Lipid droplet dependent fatty acid metabolism modulates the polarization of tumor associated macrophages". Finally, Prof. Dr. Ciro Isodoro concluded with a short talk entitled "How soluble factors in the tumor microenvironment affect cancer cell metabolism and cancer progresion: focus on autophagy". All presentations were followed by a fruitful discussion and Q&A session moderated by the chairs.

The webinar was offered via Zoom and required registration to attend. The full recording can be found here on Sciforum website.


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Relevant Special Issue

Epigenetic and Metabolic Alterations in the Tumor Microenvironment
Guest Editor: Prof. Dr. Danny N. Dhanasekaran, Prof. Dr. Ciro Isidoro
Deadline for manuscript submissions:10 October 2021.

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